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General information
The laboratory was founded by the project “Biotechnology of New Materials” in SibFU, Institute of Fundamental Biology and Biotechnology, which had won the competition for the mega-grants of Russian Federation Government within the framework of the program to support research in Russian higher education institutions, supervised by the world leading scientists.
 
The project is focused on the establishment of the Center of biotechnology excellence; it includes fundamental research, educational and innovative activities in the field of biotechnology of new biomaterials.
 
The project is fulfilled by the Basic department of Biotechnology, involving the department for Medical Biology and others from SibFU, and resulted with the creation of the Lab of New Materials.
Энтони Дж. Сински (21Кб)
The project is supervised by the world-class leading scientist -Prof. Anthony J. Sinskey, famous in the field of biotechnology of molecular genetic, metabolomics and microbiology. Prof. Sinskey has significant experience in research and realization of his ideas in the field of metabolic engineering, aimed to the obtaining of target products, focusing on fundamental physiology, biochemistry and molecular genetics.
 

 
 
 
Laboratory of Biotechnology of New Biomaterials
The Laboratory was founded in the frames of mega-project, which was supervised by professor Anthony John Sinskey, the world-famous scientist in biotechnology. Professor Sinskey has significant experience in research of metabolic engineering, focused on fundamental physiology, biochemistry and molecular genetics of microorganisms. In particular, he is studying the key factors that regulate the synthesis of valuable products, mainly biodegradable polymers – polyhydroxyalkanoates (PHA). Fundamental results of Prof. Sinskey’s research are the basis of modern biotechnology and biomedicine. Prof. Sinskey is also the Academic Advisor of the Centre for Biomedical Innovations at IT located at the Engineering Systems Division. As the supervisor of research teams, committees, educational projects and programmes Prof. A. Sinskey has been always organizing the work of the team in such a way, that all the target objectives, independently of their complicacy, have been done in full and at the top-quality level.
 
Under the supervision of Prof. A. Sinskey scientific and business projects have been carried out, that have played an important role in the area of development and widening of biotechnology as the field of knowledge and the industrial area.
 
Total number of publications (1964 – present) – 322
Citation index – 5975
Number of articles that refer to the research field and have been published in scientific journals indexed by Russian and international organizations – 194
H-index – 42
Citation index of 10 most significant publications – 2115
Summary impact-factor of the publications for 2005-2009 as of December 2009, evaluation by 2008 by JCR Science Edition – 141,01
 
Education:
InstitutionDegreePeriod
University of Illinois
Urbana, Illinois
B.S.1958-1962
Massachusetts Institute of Technology
Cambridge, Massachusetts
Sc.D.1962-1966
Harvard School of Public Health
Boston, Massachusetts
Post Doctoral Fellowship1967-1968
 
Major Research Interests:
 
  • Microbiology
  • Biotechnology
  • Metabolic and Biopolymer Engineering
  • Mammalian Cell Culture
 
Experience:
2009 - PresentProfessor of Engineering SystemsEngineering Systems Division
Massachusetts Institute of Technology
2004 - PresentProfessor of Health Sciences and TechnologyDept. of the Harvard-MIT Division of Health Sciences and Technology
Massachusetts Institute of Technology
1998 - PresentProfessor of MicrobiologyDept. of Biology
Massachusetts Institute of Technology
1988 - 1998Professor of MicrobiologyDept. of Biology
and Associate Director
Biotechnology Process Engineering Ctr.
Massachusetts Institute of Technology
1977 - 1988Professor of Applied MicrobiologyDept. of Applied Biological Sciences
Massachusetts Institute of Technology
 
List of the most significant publications:
  1. Hwang, C., Sinskey, A.J., Lodish, H.F. Oxidized redox state of glutathione in the endoplasmic-reticulum. Science. 1992. 257(5076): 1496-1502 (833 citations)
  2. Peoples, O.P., Sinskey, A.J. Poly-beta-hydroxybutyrate (PHB) biosynthesis in alcaligenes-eutrophus H16 - identification and characterization of the PHB polymerase gene (PhbC). Journal of Biological Chemistry. 1989. 264 (26): 15298-15303 (232 citations)
  3. Valge, V.E., Wong, J.G.P., Datlof, B.M., Sinskey, A.J., Rao, A. Protein kinase-C is required for responses to T-cell receptor ligands but not to interleukin-2 in T-cells. Cell. 1988. 55 (1): 101-112 (218 citations)
  4. Glacken, M.W., Fleischaker, R.J., Sinskey, A.J. Reduction of waste product excretion via nutrient control - possible strategies for maximizing product and cell yields on serum in cultures of mammalian-cells. Biotechnology and Bioengineering. 1986. 28 (9): 1376-1389 (207 citations)
  5. Peoples, O.P., Sinskey, A.J. Poly-beta-hydroxybutyrate biosynthesis in Alcaligenes eutrophus H16 - characterization of the genes encoding beta-ketothiolase and acetoacetyl-CoA reductase. Journal of Biological Chemistry. 1989. 264 (26): 15293-15297 (179 citations)
  6. Von der Osten, C.H., Sinskey, A.J., Barbas, C.F., Pederson, R.L., Wang, Y.F., Wong, C.H. Use of a recombinant bacterial fructose-1,6-diphosphate aldolase in aldol reactions - preparative syntheses of 1-deoxynojirimycin, 1-deoxymannojirimycin, 1,4-dideoxy-1,4-imino-d-arabinitol, and fagomine. Journal of the American Chemical Society. 1989. 111 (11): 3924-3927 (138 citations)
  7. Yoshihama, M., Higashiro, K., Rao, E.A., Akedo, M., Shanabruch, W.G., Follettie, M.T., Walker, G.C., Sinskey, A.J. Cloning vector system for Corynebacterium glutamicum. Journal of Bacteriology. 1985. 162 (2): 591-597 (136 citations)
  8. Gerngross, T.U., Snell, K.D., Peoples, O.P., Sinskey, A.J., Csuhai, E., Masamune, S., Stubbe, J. Overexpression and purification of the soluble polyhydroxyalkanoate synthase from Alcaligenes eutrophus - evidence for a required posttranslational modification for catalytic activity. Biochemistry. 1994. 33 (31): 9311-9320. (129 citations)
  9. Glacken, M.W., Adema, E., Sinskey, A.J. Mathematical descriptions of hybridoma culture kinetics. 1. Initial metabolic rates. Biotechnology and Bioengineering. 1988 32 (4): 491-506. (129 citations)
  10. Nielsen, U.B., Cardone, M.H., Sinskey, A.J., MacBeath, G., Sorger, P.K. Profiling receptor tyrosine kinase activation by using Ab microarrays. Proceedings of the National Academy of Sciences of the United States of America. 2003. 100 (16): 9330-9335 (120 citations).
 
The complex program of the project is focused on the establishment of the Center for Biotechnology Excellence at SibFU as one of the priority fields of the University development. It includes fundamental research, educational and innovative activities in the field of biotechnology of new biomaterials.
 
The project is carried out by the Basic Chair for Biotechnology with involvement of the Chair for Medical Biology and the Chair for Biophysics of the SibFU Institute of Fundamental Biology and biotechnology.
Prof. Ekaterina Shishatskaya, Head of Division of Medical Biology in SibFU, Co-supervisor of the project.
© Siberian Federal University, 2010–2013
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